DLBCL, MM

  • R chop therapy for DLBCL
    • diffuse large B cell lymphoma
    • standard therapy is R-CHOP therapy
      • rituximab
      • cyclophosphamide
      • doxorubicin
      • vincristine
      • prednisolone
    • B cell signalling pathway
      • it might be interesting to think B-cell signalling statistically.
      • - statistical genetics
      • - statistical physics
      • - statistical fluid dynamics
        • flow on signal pathway
      • - statistical pharmacology
        • action of drug is stochastic events in micro scale, side effect are events in macro scale.

MM

www.mayoclinic.org

  • Diagnosis of multiple myeloma
    • Blood tests
      • M proteins by myeloma celss
      • beta 2 microglobulin
    • Urine test
      • M proteins
    • Examination of your bone marrow
      • FISH, gene mutation
    • Imaging tests
  • Treatment of multiple myeloma
    • targeted therapy
    • immunotherapy
    • chemotherapy
    • bone marrow transplant
    • radiation therapy
  • complications
    • bone pain, kidney, infections, bone loss, anemia
  • Multiple myeloma. more information which I need.
  • So, I look up up-to-date paper for multiple myeloma on PubMed.
  • reference
  • Rajkumar S. V. (2022). Multiple myeloma: 2022 update on diagnosis, risk stratification, and management. American journal of hematology, 97(8), 1086–1107. https://doi.org/10.1002/ajh.26590
  • so, let us look it up.
    • risk stratification
      • by checking genetic information, we can get some risk for both mortality and complications, and outcome of therapy
    • risk adapted initial therapy
      • autologou stem cell transplantation
        • bortezomib, lenalidomide, dexamethasone (VRd)
        • when risk is high, + daratumumab
      • not
  • on the way of writing this document, I found nice paper that handle math modelling of hematopoietic stem cell.